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Pigment dispersing factor : ウィキペディア英語版 | Pigment dispersing factor
''Pigment dispersing factor (pdf)'' is a gene that encodes for the protein PDF, which is part of a large family of neuropeptides. Its hormonal product, pigment dispersing hormone (PDH), was named for the diurnal pigment movement effect it has in crustacean retinal cells, and was initially discovered in the central nervous system of arthropods.〔 The movement and aggregation of the pigments in retina cells and extra-retinal cells is hypothesized to be under a split hormonal control mechanism.〔 One hormonal set is responsible for concentrating chromatophoral pigment and responds to changes in the length of darkness presented to the organism whereas another set is responsible for dispersion and responds to the light cycle.〔 However, insect PDF genes do not function in such pigment migration since they lack the chromatophore.〔The Interactive Fly () 2011 Apr 28.〕 The gene was first isolated and studied in ''Drosophila'' by Jeffrey C. Hall's laboratory at Brandeis University in 1998, and has been found to function as a neuromodulator in controlling circadian rhythms. ==Gene characteristics== In ''Drosophila'', the ''pdf'' gene is intronless and is located at 97B on the third chromosome.〔National Center for Biotechnology Information: Pdf Pigment-dispersing factor (Drosophila melanogaster). () 2011 Mar 29.〕 It exists in a single copy per haploid genome and the approximately 0.8 kb transcript is expressed in the ''Drosophila's'' head.〔 The cDNA clone in flies has 1080 base pairs with a single exon.〔 Six alleles of this gene have been reported and are found in dorsal lateral neurons and the ventral lateral neurons in the ''Drosophila'' brain.〔Flybase: A Database of Drosophila Genes & Genomes. () 2011 Apr 27.〕
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